Mycobacterial recombinants and peptides

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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424 88, 435 7, 4351723, 530324, 530325, 530326, 530327, 530329, 530330, 530333, 530350, 536 27, A61K 3902, A61K 3702, C07K 300

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active

049769588

ABSTRACT:
Recombinant 540 amino acid residue and 517 amino acid residue proteins encoded by the genome of Mycobacterium tuberculosis are disclosed as are vectors for propagating their DNA sequences and expressing the proteins. Also disclosed are methods for using those proteins. Peptides that correspond substantially to the sequences of those proteins and methods of their use are also disclosed, as are polymers containing peptide repeating units corresponding to the 540 residue protein and also polymers containing 517 protein pentapeptides as repeating units.

REFERENCES:
patent: 4489158 (1984-12-01), Straus
patent: 4575484 (1986-03-01), Straus
patent: 4689397 (1987-08-01), Shinnick et al.
patent: 4724144 (1988-02-01), Rook et al.
Mehra et al, "Efficient Mapping of Protein Antigenic Determinants", Proc. Natl. Acad. Sci. U.S.A., vol. 83, pp. 7013-7017, 1986.
Shinnick et al, "The Etiologic Agents of Leprosy and Tuberculosis Share an Immunoreactive Protein Antigen with the Vaccine Strain Mycobacterium bovis BCG", Infect. Immunity, vol. 55, No. 8, pp. 1932-1935, 1987.
Kingston et al, "Immunological Activity of a 14-KD Recombinant Protein of Mycobacterium tuberculosis, H37 RV," Infect. Immunity, vol. 55, No. 12, pp. 3149-3154, 1987.
Young et al., Proc. Natl. Acad. Sci. U.S.A. 82: 2583-2587 (1985).
Kaufmann et al., Eur. J. Immun. 17:351-357 (1987).
Lu et al., Infect. Immun. 55:2378-2382 (1987).
Emmrich et al., J. Exp. Med. 163:1024-1029 (1986).
Mustafa et al., Nature 319:63-66 (1986).
Gillis et al., Infect. Immun. 49:371-377 (1985).
Thole et al., Infect. Immun. 50:800-806 (1985).
Engers et al., Infect. Immun. 51:718-720 (1986).
Engers et al., Infect. Immun. 48:603-605 (1985).
Melancon-Kaplan et al., Proc. Natl. Acad. Sci. U.S.A. 85:1917-1921.
Mustafa et al., Lepr. Rev. 57, Suppl. 2:123-130 (1986).
Boom et al., Infect. Immun. 55:2223-2229 (1987).
Oftung et al., J. Immunol. 141:2749-2754 (1988).

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