Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2001-06-21
2010-06-29
Swartz, Rodney P. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S009100, C424S009200, C424S184100, C424S185100, C424S190100, C424S192100, C424S234100, C424S248100, C424S278100, C435S007200, C530S300000, C530S350000
Reexamination Certificate
active
07745141
ABSTRACT:
A number of protein and glycoprotein antigens secreted by, or expressed on the surface of,Mycobacterium tuberculosis(Mtb) have been identified as “early” Mtb antigens on the basis of antibodies present in subjects infected with Mtb prior to the development of detectable clinical disease. PirG protein encoded by the Mtb gene Rv3810, PE-PGRS protein encoded by the Mtb gene Rv3367, PTRP protein encoded by the Mtb gene Rv0538) and MtrA protein encoded by the Mtb gene Rv3246c, or epitopes of these proteins, are useful in immunoassay methods or T cell assays for early, rapid detection of TB in a subject. Preferred immunoassays detect antibodies in the urine. Also provided are antigenic compositions, kits and methods useful for detecting these early Mtb antigens and early Mtb antibodies specific for them. Vaccine compositions comprising the foregoing antigens or epitopes are also disclosed.
Laal Suman
Zolla-Pazner Susan
Browdy and Neimark PLLC
New York University
Swartz Rodney P.
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