Mycobacteria expressing HIV-1 and malaria antigens

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Reexamination Certificate

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C424S009100, C424S009200, C424S200100, C424S201100, C424S208100, C424S234100, C424S093400, C424S248100, C435S041000, C435S069100, C435S069300, C435S071100

Reexamination Certificate

active

07998471

ABSTRACT:
Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided areMycobacterium smegmatisexpressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and the malarial pathogen. Additionally provided are methods of inducing an immune response in a mammal against HIV-1 and a malarial pathogen. Also provided are methods of inducing an immune response in a mammal against HIV-1. The methods comprise infecting the mammal with any of the above-described mycobacteria.

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