Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-10-08
2000-03-21
Burke, Julie
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, 530827, 514 12, C07K 1447, A61K 3817
Patent
active
060404256
ABSTRACT:
The present invention provides a novel MHRII-associated protein designated MHRII-AP62 and antibodies immunoreactive with the MHRII-AP62 protein. Also provided are kits containing these antibodies and methods of using the antibodies for the detection of the MHRII-AP62 protein. The present invention also provides for a nucleic acid encoding the MHRII-AP62 protein and nucleic acid probes for use in the detection of the MHRII-AP62 protein. Further provided by the present invention are agents that mimic the activity of the MHRII-AP62 protein by binding to the MHRII, agents that inhibit the activity of the MHRII-AP62 protein by binding to the MHRII-AP62 protein, or by binding to the nucleic acid encoding the MHRII-AP62 protein, and methods of using these agents to treat cancer and cancer causing diseases.
REFERENCES:
Burgess et al J Cell Biol vol. 111 2129-2138, Nov. 1990.
Lazar et al Molecular and Cellular Biology vol. 8 No. 3 1247-1252, Mar. 1988.
Schwartz et al Proc Natl Acad Sci USA vol. 84 6408-6411, 1987.
Lin et al Biochemistry vol. 14 1559-1563, 1975.
Acland et al Nature vol. 343 662-665, 1990.
Creighton, TE Proteins: Structure and Molecular Principles, WH Freeman and Co NY 93-94, 1983.
Creighton, TE Prog Biophys Molec Biol vol. 33 231-233, 1975.
Rao, et al., Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression domain of the Myc antagonist Mxil, Oncogene, vol. 12, pp. 1165-1172 (1996).
Schrelber-Agus, et al., An Amino-Terminal Domain of Mxil Mediates Anti-Myc Oncogenic Activity and Interacts with a Homolog of the Yeast Transcriptional Repressor SIN3, Cell, vol. 80, pp. 777-786 (1995).
Gomez-Lahoz, et al., Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxil, Proc. Natl. Acad. Sci. USA, vol. 91, pp. 5503-5507 (1994).
Koskinen, et al., Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein interactions, Cell Growth Differ., 6(6):623-9 (1995).
Depinho, et al., Myc Family of Cellular Oncogenes, J. Cell Biochem., 33(4):257-66 (1987).
Schreiber-Agus, et al., A biochemical and biological analysis of Myc superfamily interactions, Curr. Top. Microbiol. Immunol., vol. 224, pp. 159-168 (1997).
Alland, et al., Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression, Nature, 387 (6628):49-55 (1997).
Schreiber-Agus, et al., Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype, Proc. Natl. Acad. Sci. USA ($(4):1235-40 (1997).
Chin, et al., Contrasting roles for Myc and Mad proteins in cellular growth and differentiation, Proc. Natl. Acad. Sci. USA 92(18):8488-92 (1995).
Chen, et al., Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phentotype of human brain tumor cells, Nat. Med., 1(7):638-43 (1995).
Chin, et al., Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development, J. Investig. Dermatol. Symp. Proc., 1(2):128-35 (1996).
Mukherjee, et al., Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants, Genes Dev., 6(8): 1480-92 (1992).
Torres, et al., Myc and Max: a putative transcriptional complex in search of a cellular target, Curr. Opin. Cell Biol., 4(3):468-74 (1992).
Albert Einstein College of Medicine of Yeshiva University
Burke Julie
LandOfFree
Myc homology region II--associated protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Myc homology region II--associated protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Myc homology region II--associated protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-731352