MVL, an antiviral protein from a cyanobacterium

Details MVL, an antiviral protein from a cyanobacterium MVL, an antiviral protein from a cyanobacterium

2011-06-21

2011-06-21

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C422S032000, C502S007000, C502S403000, C514S003800, C514S021300, C530S324000, C530S825000

Reexamination Certificate

active

07964559

ABSTRACT:
The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium,Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1→6)Man-beta (1→4) GlcNAc-beta(1→4)GlcNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.

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