Muteins of tumor necrosis factor

Details Muteins of tumor necrosis factor Muteins of tumor necrosis factor

1988-07-26

1991-07-02

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 695, 4353201, 536 27, C07K 1300, A61K 3702

Patent

active

050284207

ABSTRACT:
A novel physiologically active polypeptide having antitumor activity obtained by improving human tumor necrosis factor (TNF). The amino acid sequence of the polypeptide essentially corresponds to that of human tumor necrosis factor, except that ten amino acids Nos. 1 to 10 are deleted and (Met).sub.n -Arg-Lys-Arg are added to the amino (NH.sub.2)-terminus, where n is 0 or 1. Other amino acid modifications can also be made to the polypeptide while retaining high antitumor activity. The novel polypeptide has less side effects that the natural-type TNF, particularly with respect to cytotoxicity. A a DNA fragment encoding the polypeptide, a recombinant plasmid containing the DNA fragment, a recombinant microorganism cell transformed with the plasmid, a method of producing a novel physiologically active polypeptide using the microorganism cell, and a pharmaceutical composition comprising the polypeptide as an active ingredient are also provided.

REFERENCES:
patent: 4677063 (1987-06-01), Mark
Tavernier, J. et al., "Isolation and Expression of the Genes Coding for Mouse & Human Tumor Necrosis Factor. . . " Lymphobines, vol. 3, pp. 181-188, 1987.

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