Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-12-21
1996-05-21
Adams, Donald E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 691, 435 695, 435 697, 4352523, 43525233, 4353201, 53395, 53402, C12N 1500, C12N 1509, A61K 3819
Patent
active
055191193
ABSTRACT:
A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of Arg-Gly-Asp and from 3 to 16 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.
REFERENCES:
patent: 4948875 (1990-08-01), Tanaka et al.
patent: 4990455 (1991-02-01), Yamagishi et al.
patent: 5028420 (1991-07-01), Masegi et al.
patent: 5180811 (1993-01-01), Doerper et al.
Malik Cancer Lit Abstract 00979234 1991.
Van Ostade Nature 361:266-269 1993.
Ruoslahti et al Cancer Cells 1(4):119-126 1989.
Aoyama Yoshiyuki
Kato Masanari
Miyata Keizo
Shikama Hiroshi
Yamada Nobutoshi
Adams Donald E.
Ishihara Sangyo Kaisha Ltd.
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