Muteins of the granulocyte colony stimulating factor

Details Muteins of the granulocyte colony stimulating factor Muteins of the granulocyte colony stimulating factor

1992-10-14

1995-03-21

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

435 695, 530351, 930145, 514 12, A61K 3100, C07K 1300, C12P 2100

Patent

active

053993454

ABSTRACT:
A granulocyte stimulating factor (G-CSF) or a G-CSF variant differs from natural G-CSF in that one or several amino acids of the sequence ##STR1## at position 50 to 56 of the mature G-CSF with 174 amino acids or at position 53 to 59 of the mature G-CSF with 117 amino acids or/and at least one of the 4 His residues at position 43, 79, 156 or 170 of the mature G-CSF with 174 amino acids position 46, 82, 159 or 173 of the mature G-CSF with 177 amino acids are mutagenized. It is suitable for immunotherapy.

REFERENCES:
patent: 4810643 (1989-03-01), Souza
Okake et al., Blood, 75, 1990, pp. 1788-1793.
Gaertner et al., Bioconjugate Chem., 3(3), 1992, pp. 262-268, (abstract only).
Itoh et al., "Effects of Recombinant Human G-CSF on Primary Human Leukemic Cells", Acta Haematologica Japonica, pp. 988-995, (1989).

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