Muteins of the CGRP 1-7 peptide fragment and use thereof as...

Details Muteins of the CGRP 1-7 peptide fragment and use thereof as... Muteins of the CGRP 1-7 peptide fragment and use thereof as...

2006-04-18

2006-04-18

Landsman, Robert S. (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S307000, C530S329000, C530S330000

Reexamination Certificate

active

07030081

ABSTRACT:
Muteins of the Ser-Cys-Asn-Thr-Ala-Thr-Cys sequence from the N-terminal 1-7 fragment of the CGRP peptide, possessing an enhancing action on the activation of neuronal nicotinic receptors, their pharmaceutical compositions containing the same and their use for the potential therapy of neurological diseases are described.

REFERENCES:
Mimeault et al. (1993), Eur. J. Biochem. 213(3): 927-934.
Di Angelantonio et al. (2002), Mol. Pharmacol. 61(1): 43-54.
Nistri et al. (2002), Ann. N. Y. Acad. Sci. 971: 100-107.
Katsuya et al., “Calcium-dependent enhancing effect by calcitonin gene-related peptide on muscle nicotinic receptor desensitization”, Japanese Journal of Pharmacology, vol. 79, No. suppl. 1 (1998).
Giniatullin et al., “Calcitonin gene-related peptide rapidly downregulates nicotinic receptor function and slowly raises intracellular Ca2+ in rat chromaffin in vitro”, J. of Neuroscience vol. 19, No. 8, p. 2945-53, (1999).
Trevor et al., “Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues evidence for receptor multiplicity”, J. of Pharmacology & Experimental Therapeutics, vol. 251, No. 2, p 718-25, (1989).

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