Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2007-12-31
2010-10-05
Bunner, Bridget E (Department: 1649)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
C514S002600, C530S350000
Reexamination Certificate
active
07807178
ABSTRACT:
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing the derivatives. The invention likewise relates to the production of antibodies for the derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
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Bailey et al., Stroke; 2009; 40: e451-e458.
Lutton et al. (Nature Medicine, 2002; 8: 831-840.
Liu et al., Brain, 2006; 129: 2734-2745.
Iyer et al., JBC, 2001; 276: 12153-12161.
Beusse Wolter Sanks Mora & Maire
Borgeest Christina
Bunner Bridget E
Geymonat S.p.A.
Van Dyke Timothy H.
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