Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2008-01-01
2008-01-01
O'Hara, Eileen (Department: 1649)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C530S350000, C530S399000, C514S012200, C435S069400, C435S320100, C435S252800, C435S006120, C435S091200, C536S023500, C536S024100
Reexamination Certificate
active
10514707
ABSTRACT:
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
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patent: WO 92/06194 (1992-04-01), None
patent: WO 01/85796 (2001-11-01), None
Wells, 1990, Biochemistry 29:8509-8517.
Ngo et al., 1994, The Protein Folding Problem and Teritary Structure Prediction, pp. 492-495.
Errico et al. J Biol Chem. 2004;279: 43929-39.
Saragovi & Burgess, Exp Opin Ther Patents. 1999; 9: 737-751, p. 739, left column, 2nd paragraph.
Cao et al. Biochem Biophys Res Comm. 1997; 235: 493-498.
Battisti Mauro
Conti Ettore
Maglione Domenico
Mion Alberto
Salvia Giuseppe
Beusse Wolter Sanks Mora & Maire, P.A.
Borgeest Christina
Fischer Joseph
O'Hara Eileen
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