Muteins of placental growth factor type 1, preparation...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C530S350000, C530S399000, C514S012200, C435S069400, C435S320100, C435S252800, C435S006120, C435S091200, C536S023500, C536S024100

Reexamination Certificate

active

10514707

ABSTRACT:
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.

REFERENCES:
patent: 5994300 (1999-11-01), Bayne et al.
patent: WO 92/06194 (1992-04-01), None
patent: WO 01/85796 (2001-11-01), None
Wells, 1990, Biochemistry 29:8509-8517.
Ngo et al., 1994, The Protein Folding Problem and Teritary Structure Prediction, pp. 492-495.
Errico et al. J Biol Chem. 2004;279: 43929-39.
Saragovi & Burgess, Exp Opin Ther Patents. 1999; 9: 737-751, p. 739, left column, 2nd paragraph.
Cao et al. Biochem Biophys Res Comm. 1997; 235: 493-498.

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