Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1994-08-01
1997-12-09
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 6952, 514 2, 514 12, 424 852, C07K 1454, A61K 3820
Patent
active
056962347
ABSTRACT:
Methods for screening for partial agonists and for antagonists of mammalian cytokines. Particular positions of natural cytokines are identified as critical in providing these receptor mediated properties. Specific embodiments demonstrate properties of variations at these positions.
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Zurawski Gerard
Zurawski Sandra M.
Ching Edwin P.
Mertz Prema
Mohan-Peterson Sheela
Schering Corporation
Ulm John
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