Muteins of IFN-.beta.

Details Muteins of IFN-.beta. Muteins of IFN-.beta.

1994-03-15

1996-08-13

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 856, 536 2352, 514 12, 435 6951, 4353201, 4352523, 530351, C12N 1522, C07K 14565

Patent

active

055457231

ABSTRACT:
A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an IFN-.beta. mutein, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing IFN-.beta. muteins and methods of using those compositions to treat viral infections, cancer or tumors or for immunomodulation.

REFERENCES:
patent: Re33653 (1991-07-01), Mark et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4530787 (1985-07-01), Shaked et al.
patent: 4572798 (1986-02-01), Koths et al.
patent: 4588585 (1986-05-01), Mark et al.
patent: 4737462 (1988-04-01), Mark et al.
patent: 4738844 (1988-04-01), Bell et al.
patent: 4738845 (1988-04-01), Bell et al.
patent: 4751077 (1988-06-01), Bell et al.
patent: 4753795 (1988-06-01), Bell et al.
patent: 4769233 (1988-09-01), Bell et al.
patent: 4793995 (1988-12-01), Bell et al.
patent: 4816440 (1989-03-01), Thomson
patent: 4853332 (1989-08-01), Mark et al.
patent: 4914033 (1990-04-01), Bell et al.
patent: 4959314 (1990-09-01), Mark et al.
patent: 4992271 (1991-02-01), Fernandes et al.
patent: 5183746 (1993-02-01), Shaked et al.
Berthold, Wolfgang, et al., European Journal of Biochemistry, vol. 87, 367-370 (1978).
Borukhov, Sergey I., et al., Biochemical and Biophysical Research Communications, vol. 167, No. 1, 74-80 (1990).
Khosrovi, Bezhad, Interferon: Research, Clinical Application, and Regulatory Consideration, Proceedings of an International Workshop, 89-99 (1983).
Mark, D. F., et al., Proceedings of National Academy of Science USA, vol. 81, 5662-5666 (1984).
Otto, Michael J., et al., Journal Of Virology, vo. 35, No. 2, 390-399 (1980).
Shepard, H. Michael, et al., Nature, vol. 294, No. 5841, 563-565 (1981).
Stewart, A. G., et al., DNA--A Journal of Molecular Biology, vol. 6, No. 2, 119-128 (1987).

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