Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-08-18
2000-10-03
Hauda, Karen M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435375, 4353201, 530350, A61K 3800, C12N 1524
Patent
active
061273325
ABSTRACT:
A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an IFN-.beta. mutein, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing IFN-.beta. muteins and methods for treating viral infections, cancer or tumors, undesired cell proliferation, or for immunomodulation.
REFERENCES:
Aulitzky, W.E. et al., Recombinant interferon beta in chronic myelogenous leukemia, Sem. Hemat. 30, pp. 14-16 (1993).
Basso, P. and Verdi, F., Trattamento con beta-interferone nelle infezioni da HPV dell'apparato genitale femminile, Minerva Ginecol. 44, pp. 181-184 (1992) (Abstract in English).
Cimino, T. et al., Forme istologiche di epatite cronica e risposta al trattamento con interferoni, Minerva Med 84, pp. 681-685 (1993) (Abstract in English).
Duggan, D.B. et al., A phase II study of recombinant interleukin-2 with or without recombinant interferon-.beta. in non-Hodgkins lymphoma. A study of the cancer and Leukemia group B, Journal of Immunotherapy 12, pp. 115-122 (1992).
Gomi, K. et al., Antitumor effect of human recombinant interferon-.lambda. and .beta. against human osteosarcoma transplanted into nude mice, J. Pharmacobio-Dyn. 9, pp. 879-888 (1986).
Gresser, I., Pronounced Antiviral Activity of Human Interferon on Bovine and Porcine Cells, Nature, 251, pp. 543-545 (1974).
Hertzog, Paul J., et al., Role of Interferons in the Regulation of Cell Proliferation, Differentiation, and Development, Molecular Reproduction and Development, 39, pp. 226-232 (1994).
Higgins, P.G. et al., Interferon-.beta..sub.ser as phrophylaxis against experimental rhinovirus infection in volunteers, Journal of Interferon Research 6, pp. 153-159 (1986).
Horoszewicz, J.S. et al., Human Fibroblast Interferon in Human Neoplasia: Clinical and Laboratory Study, Cancer Treatment Reports, 62, pp. 1899-1906 (1978).
Jacobs, L.D. Intramuscular Interferon Beta-la For Disease Progression in Relapsing Multiple Sclerosis, Annals of Neurology, 39(3), pp. 285-294 (1996).
Kinney, P. et al., Phase II trial of Interferon-beta-serine in metastatic renal cell carcinoma, J. Clin. Oncol. 8, pp. 881-885 (1990).
Kunder, S.C. et al., Biological response modifier-mediated resistance to herpesvirus infections requires induction of .alpha./.beta. interferon, Antiviral Research 21, pp. 129-139 (1993).
Nemato, T. et al., Human Interferons and Intralesional Therapy of Melanoma and Breast Carcinoma (Proceedings of AACR and ASCO), Abstract 993, p. 246.
Ohno, R., Interferons in the treatment of multiple myeloma, Int. J. Cancer Suppl. 1, pp. 14-20 (1987).
Ozzello, L. et al., Antiproliferative effects of natural interferon beta alone and in combination with natural interferon gamma on breast carcinomas in nude mice, Breast Cancer Research 16, pp. 89-96 (1990).
Paty, D.W. et al., Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, Neurology 43, pp. 662-667 (1993).
Schmidt, C.A. et al., Detection of allelic loss within .beta.1-interferon gene in childhood acute lymphoblastic leukemial using differential PCR, Ann. Hemat. 68, pp. 171-174 (1994).
Shephard, H. Michael, et al., A Single Amino Acid Change in IFN-.beta..sub.1 Abolishes its Antiviral Activity, Nature, 294, pp. 563-565 (Dec. 1981).
Sica, G. et al., Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells, Cancer 60, pp. 2419-2423 (1987).
Stuzziero, E. and Corbo, M., I1 beta interferone nella pratica clinica, Minerva Ginecol. 46, pp. 487-489 (1994) (Abstract in English).
Stuart-Harris, R.C. et al., The clinical application of the interferons: a review, The Medical Journal of Australia 156, pp. 869-872 (1992).
Torigoe, S. et al., Cytofluorographic analysis of effects of interferons on expression of human cytomegalovirus proteins, Journal of Virological Methods 45, pp. 219-228 (1993).
Wiernik, P.H. et al., Successful treatment of Hairy Cell Leukemia with .beta.-ser interferon, American Journal of Hematology 33, pp. 244-248 (1990).
Winkler, K. et al., Treatment of osteosarcoma: Experience of the cooperative osteosarcoma study group (COSS), Osteosarcoma in adolescents and young adults, Cancer treatment and Research 62, pp. 269-277 (1993).
Wintergerst, U. and Belohradsky, B.H., Acyclovir monotherapy versus Acyclovir plus Beta-Interferon in focal viral encaphalitis in children, Infection 20, pp. 207-212 (1992).
Worm, M. et al., Responsiveness to interferon treatment of human melanoma cells correlates to immunophenotype, Melanoma Research 3, pp. 29-33 (1993).
Wu, S. et al., A study on the relationship between the N terminal variation of human interferon .beta. and its antiviral activity, Immunochemistry 109, p. 515 (1988) (abstract only).
Yung, W.K.A., et al., A pilot study of recombinant interferon beta (IFN-.beta..sub.ser) in patients with recurrent glioma, Journal of Neuro-Oncology 9, pp. 29-34 (1990).
The Houston Chronicle, May 28, 1996. "Patients Suffering from MS Now Have Second Drug Option".
The New York Times, May 18, 1996. "F.D.A. Approves a Biogen Drug for Treating Multiple Sclerosis".
Wall Street Journal, May 20, 1996. "New Drug Aims to Win Over MS Sufferers".
USA Today, May 20, 1996. "Second MS Drug Now On the Market".
Cate Richard L.
Chow E. Pingchang
Goelz Susan E.
Pepinsky R. Blake
Biogen Inc.
Hanley, Jr. James F.
Hauda Karen M.
Miller Scott D.
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