Muteins of human erythropoietin, the preparation thereof and the

Details Muteins of human erythropoietin, the preparation thereof and the Muteins of human erythropoietin, the preparation thereof and the

1994-07-06

1995-10-10

Furman, Keith C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 424 851, 435 694, A61K 3818, A61K 3819, A61K 3822, A61K 3817

Patent

active

054570891

ABSTRACT:
The invention relates to muteins of human erythropoietin (EPO) in the carboxyl terminal region which are prepared by means of recombinant DNA techniques. These mutants have advantageous properties in comparison with human wild-type EPO.

REFERENCES:
patent: 4703008 (1987-10-01), Lin
patent: 4835260 (1989-05-01), Shoemaker
Rolson et al. 1986. Introduction to Protein and Protein Engineering, Elsevier, New York, N.Y. p. 41.
Jacobs et al., Nature, 313:806-809 (1985).
Dordal et al., Endocrinology, 116:2293-2299 (1985).
Letsinger et al., J. Amer. Chem Soc., 97:3278-3279 (1975).
Letsinger et al., J. Amer. Chem Soc., 98:3655-3661 (1976).
Morinaga et al., Bio/Technology, 7:636-639 (1984).
Kramer et al., Nucl. Acids. Res. 12:9441-9456.
Sanger et al., Proc. Natl. Acad. Sci., USA 74:5463-5467 (1977).
Zettlmeissl et al., Behring Inst. Mitt., 82:26-34 (1988).
Graham et al., Virology, 52:456-467 (1973).
Lee et al., Nature (London), 294:228-232 (1981).
Hudziak et al., Cell, 31:137-146 (1982).
Hales et al., Biochem., J., 88:137-146 (1983).
Tejedor et al., Analyt. Biochem., 127:143-149 (1982).
Smith et al., Analyt. Biochem., 150:76-85 (1985).
Krystal, J. Exp. Hematol., 11:649-660 (1983).
Recny et al., J. Biol. Chem., 262:17156-63 (1987).
Bowie et al. 1990. Science 247:1306-1310.
Dayhoff et al. 1972. Atlas of Protein Sequence and Structure vol. 5 89-99.
Shoemaker et al. 1986. Molecular and Cellular Biology 6(3): 849-858.
Dube et al. 1988. J. Biol. Chem. 263(33): 17516-17521.
Rege et al. 1982. J. Lab Clin Med., 100(6): 829-843.

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