Muteins of fibroblast growth factor 21

Details Muteins of fibroblast growth factor 21 Muteins of fibroblast growth factor 21

2005-12-07

2010-02-02

Saoud, Christine J (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S399000

Reexamination Certificate

active

07655627

ABSTRACT:
The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced deamidation compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.

REFERENCES:
patent: 6716626 (2004-04-01), Itoh et al.
patent: 7491697 (2009-02-01), Beals et al.
patent: WO 01/18172 (2001-03-01), None
patent: WO 03/011213 (2003-02-01), None
patent: WO 2004/022723 (2004-03-01), None
Robinson Noah E, et al., “Deamidation of human proteins”, Proceedings of the National Academy of Sciences of the United States of America, vol. 98, No. 22, Oct. 23, 2001.
Robinson Noah E., et al., “Prediction of protein deamidation rates from primary and three-dimensional structure”, Proceedings of the National Academy of Sciences of the United States of America, vol. 98, No. 8, Apr. 10, 2001.

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