Muteins of fibroblast growth factor 21

Details Muteins of fibroblast growth factor 21 Muteins of fibroblast growth factor 21

2005-08-25

2009-11-24

Saoud, Christine J (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S399000

Reexamination Certificate

active

07622445

ABSTRACT:
The present invention relates to novel muteins of human fibroblast growth factor-21 with reduced susceptibility for proteolytic degradation when expressed in yeast. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.

REFERENCES:
patent: 6716626 (2004-04-01), Itoh et al.
patent: 7491697 (2009-02-01), Beals et al.
patent: WO 01/18172 (2001-03-01), None
patent: WO 01/18209 (2001-03-01), None
patent: WO 01/36640 (2001-05-01), None
patent: WO 01/38357 (2001-05-01), None
patent: WO 03/011213 (2003-02-01), None
patent: WO 03/059270 (2003-07-01), None
Ciechanover, Aaron, et al., “N-terminal ubiquitnation: more protein substrates join in”, Trends in Cell Biology (2004), 14(3): 103-106.
Nishimura, T., et al., “Identification of a Novel FGF, FGF-21, Preferentially Expressed in the Liver”, Biochimica et Biophysica Acta (2000), 1492(1): 203-206.
Kharitonenkov, Alexei, et al., “FGF-21 As a Novel Metabolic Regulator”, Journal of Clinical Investigation (2005), 115(6): 1627-1635.

Affiliated with

Also associated with

Rating

Muteins of fibroblast growth factor 21 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Muteins of fibroblast growth factor 21, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Muteins of fibroblast growth factor 21 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4117695