Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-09-09
1996-02-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 696, 4351723, 4352523, 4352402, 43525233, 435 701, 435 711, 435 712, 536 231, 536 235, 536 2431, 935 10, 935 11, 935 24, 935 55, 935 57, 935 66, 935 77, 935 78, 436 63, C12N 1512, C12N 1563, C12N 1500, C12Q 168
Patent
active
054928095
ABSTRACT:
The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide less reactive with von Willebrand factor. Preferably, the mutation is in the leucine rich region of GPIb.alpha., such as the substitution of phenylalanine for leucine at residue 57. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
REFERENCES:
E. Peterson et al. "Production of Recombinant Glycoprotein Ib Alpha and . . . " Clinical Research 37(2)549a (1989).
Cunningham David
Finch Clara N.
Lyle Vicki A.
Miller Jonathan L.
Prouty Rebecca
The Research Foundation of State University of New York
Wax Robert A.
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