Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1992-01-15
1994-03-29
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 9464, 435 696, 4351723, 4352523, 4353201, 435 6, 530381, 530380, 530395, 514 8, 536 235, C12N 1512, A61K 37547, A61K 3702
Patent
active
052982394
ABSTRACT:
The subject invention provides purified polypeptide encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide less reactive with von Willebrand factor. Preferably, the mutation is in the leucine rich region of GPIb.alpha., such as the substitution of phenylalanine for leucine at residue 57. DNA encoding the mutant polypeptides, as well as expression systems for the production of the mutant polypeptides, are also provided. Methods and compositions using the mutant polypeptides and DNA oligomers complementary to the mutant polypeptides are further provided.
REFERENCES:
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4745051 (1988-05-01), Smith et al.
patent: 4879236 (1989-11-01), Smith et al.
K. J. Clemetson et al., in Molecular Biology and Differentiation of Megakaryocytes, pp. 77-88 (Wiley-Liss, Inc. 1990).
A. Duperray et al., Abstract No. 26, Thrombosis and Haemostasis 65: 654 (Jun. 1991).
C. N. Finch et al., Blood 75: 2357-2362 (Jun. 1990).
R. I. Handin and E. Petersen, Abstract No. 477, Blood 74: 129A (Nov. 1989).
C. A. Hasemann and J. D. Capra, Proc. Natl. Acad. Sci. USA 87: 3942-3946 (May 1990).
J. A. Lopez et al., Proc. Natl. Acad. Sci. USA 84: 5615-5619 (Aug. 1987).
J. A. Lopez et al., Proc. Natl. Acad. Sci. USA 85: 2135-2139 (Apr. 1988).
J. A. Lopez et al., Abstract No. 2373, Circulation 82: III-597 (Oct. 1990).
V. A. Luckow and M. D. Summers, Bio/Technology 6: 47-55 (Jan. 1988).
S. Meyer et al., Abstract No. 350, Thrombosis and Haemostasis 65: 771 (Jun. 1991).
J. L. Miller, Clinics in Laboratory Medicine 4: 319-331 (Jun. 1984).
J. L. Miller et al., British Journal of Haemotology 74: 313-319 (1990).
J. L. Miller et al., Abstract No. 2364, Circulation 82: III-595 (Oct. 1990).
J. L. Miller et al., Proc. Natl. Acad. Sci. USA 88: 4761-4765 (Jun. 1991).
M. Murata et al., Abstract No. 1862, Blood 76: 468a (Nov. 1990).
M. Murata et al., Abstract No. 348, Thrombosis and Haemostasis 65: 771 (Jun. 1991).
E. Petersen et al., Abstract No. 1251, Blood 72: 225a (Nov. 1988).
M. R. Pincus et al., Abstract No. 346, Thrombosis and Haemostasis 65: 770 (Jun. 1991).
G. J. Roth, Blood 77: 5-19 (Jan. 1991).
J. Ware et al., Proc. Natl. Acad. Sci. USA 87: 2026-2030 (Mar. 1990).
N. R. Webb and M. D. Summers, Technique-A Journal of Methods in Cell and Molecular Biology 2: 173-188 (Aug. 1990).
R. H. Wenger et al., Biochem Biophys Res Commun 156: 389-395. (Oct. 1988).
R. H. Wenger et al., Gene 85: 517-524 (1989).
A. N. Wicki et al., Abstract No. 828, Abstracts of the International Society of Thrombosis and Haemostasis Meeting, Brussels, Belgium (1987).
A. N. Wicki et al., Abstract No. 829, Abstracts of the International Society of Thrombosis and Haemostasis Meeting, Brussels, Belgium (1987).
A. N. Wicki et al., Thrombosis and Haemostasis 61: 448-453 (1989).
J. Wippler et al., Abstract No. 31, Thrombosis and Haemostasis 65: 655 (Jun. 1991).
J. Ware et al., Abstract No. 1101, Blood 78: 278a (Nov. 1991).
Cunningham David
Finch Clara N.
Lyle Vicki A.
Miller Jonathan L.
Prouty Rebecca
The Research Foundation of State University of New York
Wax Robert A.
LandOfFree
Mutations rendering platelet glycoprotein IB .alpha. less reacti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutations rendering platelet glycoprotein IB .alpha. less reacti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutations rendering platelet glycoprotein IB .alpha. less reacti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-789783