Mutations of the 5′ region of the human 5-HT1A gene

Details Mutations of the 5′ region of the human 5-HT1A gene Mutations of the 5′ region of the human 5-HT1A gene

2006-05-23

2006-05-23

Hayes, Robert C. (Department: 1647)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100

Reexamination Certificate

active

07049429

ABSTRACT:
Clinical response to antidepressant compounds correlates with a selective down-regulation of presynaptic 5-HT1A receptors in serotonergic raphe neurons. Thus regulation of the 5-HT1A receptor gene could play a crucial role in the treatment or etiology of major depression. The promoter and repressor activities of the human 5-HT1A receptor gene have been examined. The analysis of the 5′-flanking regions of the 5-HT1A receptor gene has revealed a segment located between about −3438 and about −393 bp upstream from the initiator ATG that mediates cell-specific repression of the gene that is greater in cells that do not express the 5-HT1A receptor. The sequence of part of this region in patients with major depression were examined and a polymorphic C-G change located at −1017 bp was identified, which is associated with major depression. Thus, this sequence can be used as a genetic marker for major depression and related mental illnesses. A protein that binds to the DNA at the −1017 locus has been identified. Any such proteins that bind to the DNA at this region are important targets for the development of therapeutic compounds for the treatment of major depression and related mental illness that involve the serotonin system. In addition the promoter region from about −393 to the initiator ATG displays glucocorticoid-mediated repression.

REFERENCES:
LeClerc et al., Nature 297: 596-597 (1982).
“The Serotonin 1a Receptor Gene Contains a TATA-Less Promoter That Responds to MAZ and Sp1” by Parks and Shenk, The Journal of Biological Chemistry, vol. 271, No. 8, Feb. 1996, pp. 4417-4430.

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