Mutation in the rat adenomatous polyposis coli gene within...

Details Mutation in the rat adenomatous polyposis coli gene within... Mutation in the rat adenomatous polyposis coli gene within...

2011-03-01

2011-03-01

Li, Q. Janice (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

C800S003000, C800S008000, C800S009000, C536S023100

Reexamination Certificate

active

07897834

ABSTRACT:
A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny of that rat. In addition, methods of using these rats are provided, including methods for screening a carcinogen or a promoter of carcinogenesis, and methods for screening preventive and inhibitory agents of carcinogenesis.

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