Mutation assays involving blood cells that metabolize toxic subs

Details Mutation assays involving blood cells that metabolize toxic subs Mutation assays involving blood cells that metabolize toxic subs

1982-07-19

1985-07-30

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4351721, 435240, 435241, 435948, 435 6, C12Q 129, C12N 1500, C12N 502, C12R 191

Patent

active

045322040

ABSTRACT:
A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

REFERENCES:
patent: 4036693 (1977-07-01), Levine et al.
patent: 4066510 (1978-01-01), Thilly
patent: 4299915 (1981-11-01), Thilly et al.
patent: 4302535 (1981-11-01), Skopek et al.
patent: 4393133 (1983-07-01), Knowles et al.
Paigen et al, "Questionable Relation of Aryl Hydrocarbon Hydroxylase to Lung Cancer Risk", New England Journal of Medicine 297(7) (8-18-1977) pp. 346-350.
Thilly et al., "Gene-Locus Mutation Assays in Diploid Human Lymphoblast Lines", Chemical Mutagens, vol. 6, ed. Serres et al, (1980), pp. 331-364.
Cohen et al, "Large Interindividual Variations in Metabolism of Benzo-Pyrene by Peripheral Lung Tissue from Lung Cancer Patients", International Journal of Cancer 24, pp. 129-133 (1979).
Burke et al, "3-Methylcholanthrene-Induced Momoxygenase (O-Deethylation) Activity of Human Lymphocytes", Cancer Research 37, pp. 460-463 (1977).
Freedman, H. J. et al., (1979) "Aryl Hydrocarbon Hydroxylase in a Stable Human B-Lymphocyte Cell Line, RPMI-1788, Cultured in the Absence of Mitogens", Cancer Res. 39, 4605-4611.
Freedman, H. J. et al. (1979) "Induction, Inhibition and Biological Properties of Aryl Hydrocarbon Hydroxylase in a Stable Human B-Lymphocyte Cell Line, RPMI-1788", Cancer Res. 39, 4612-4619.
Tong, C. and Williams, G. M. (1978) "Induction of Purine Analog-Resistant Mutants in Adult Rat Liver Epithelial Lines by Metabolic Activation-Dependent and -Independent Carcinogens", Mutagen Res. 58, 339-352.
Tong, C. and Williams, G. M. (1980) "Definitions of Conditions for the Detection of Genotoxic Chemicals in the Adult Rat-Liver Epithelial Cell/Hypoxanthine-Guanine Phosphoribosyl Transferase (ARL/HGPRT) Mutagenesis Assay", Mutation Res. 74, 1-9.
Crespi, C., "Xenobiotic Metabolism and Mutation in Diploid Human Lymphoblasts", Ph. D. Thesis received by Library of Massachusetts Institute of Technology on Jul. 30, 1982.

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