Mutated herpes simplex virus type 1 thymidine kinases and...

Details Mutated herpes simplex virus type 1 thymidine kinases and... Mutated herpes simplex virus type 1 thymidine kinases and...

2006-03-28

2006-03-28

Qian, Celine (Department: 1636)

Chemistry: molecular biology and microbiology

Vector, per se

C435S325000

Reexamination Certificate

active

07018834

ABSTRACT:
The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.

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