Mutated gene coding for a lat protein and the biological...

Details Mutated gene coding for a lat protein and the biological... Mutated gene coding for a lat protein and the biological...

2008-07-15

2008-07-15

Ton, Thaian N (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S021000, C800S022000, C435S320100, C435S463000

Reexamination Certificate

active

07399901

ABSTRACT:
The present invention relates to a mutated gene coding for a mutant LAT protein leading to exaggerated TH2 differentiation. The invention relates to biological structures containing the mutant, particularly non-human LAT gene, mutated animals, plasmids, chromosomal DNAs, embryos comprising the mutated gene, and applications thereof. The invention further relates to screening methods for drugs useful for treatment against asthma and allergy. Otherwise, the invention relates to methods for producing IgE antibodies.

REFERENCES:
patent: WO 99/32627 (1999-07-01), None
Sommers et al., J. Exp. Med, 194(2): 135-142 (Jul. 16, 2001).
Zhang et al. Immunity, 10:323-332, Mar. 1999.
Kappell et al. Current Opinion in Biotechnology 3:548-553 (1992).
Mullins et al. Hypertension 22:630-633 (1993).
Houdebine. J. Biotech. 34:269-287 (1994).
Mullins et al. J. Clin. Invest. 97:1557-1560 (1996).
Cameron. Molec. Biol. 7:253-265 (1997).
Sigmund. Arteroscler. Throm. Vasc. Biol. 20:1425-1429 (2000).
Niemann. Transg. Res. 7:73-75 (1998).
Seffernick et al. J. Bacteriol. 183(8):2405-2410, 2001.
Witkowski et al. Biochemistry 38:11643-11650, 1999.
Moreadith et al. J. of Mol. Med. 75:208-216 (1997).
The Free Dictionary by Farlex [online], term “corresponding” [retrieved on Jul. 31, 2006]. Retrieved from the Internet,:URL: http://www.thefreedictionary.com/corresponding?p>).
Kuby, Immunology, 2ndedition, 1994, ed. W.H. Freeman and Company, p. 311.
Encyclopaedia Britannica. Retrieved Jan. 22, 2007, from Encyclopaedia Britannica Online: http://www.search.eb.com/eb/article-9105980.
Mullins. Nature, vol. 344, 541-544, 1990.
Hammer. Cell, vol. 63, 1099-1112, 1990.
Mullins, EMBO J., vol. 8, pp. 4065-4072, 1989.
Taurog, Jour. Immunol., vol. 141, pp. 4020-4023, 1988.
Charreau et al. Transgenic Research, 5:223-234 (1996).
Genton et al., The Journal of Immunology, 2006, 177:2285-2293 “The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity”.
Aguardo et al, “Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor”, Science, vol. 296, No. 5575, 2002, pp. 2036-2040.
Sommers et al, “A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferatiion”, Science, vol. 296, No. 5575, 2002, pp. 2040-2043.
Samelson et al, “Studies on the Adapter Molecule LAT”, Cold Spring Symposia on Quantitative Biology, Biological Laboratory, Cold Spring Harbor, NY, US, No. 64, 1999, pp. 259-263.
Lin et al, “Identification of the Minimal Tyrosine Residues Required for Linker for Activation of T Cell Function”, Journal of Biological Chemistry, vol. 276, No. 31, Aug. 3, 2001, pp. 29588-29595.
Zhang et al, “Association of Grb2, Gads, and Phospholipase Cyl with Phosphorylated LAT Tyrosine Residues”, Journal of Biological Chemistry, vol. 275, No. 30, Jul. 28, 2000, pp. 23355-23361.
Zhang et al, “Essential Role of LAT in T Cell Development”, Immunity, vol. 10, No. 3, Mar. 1999, pp. 323-332.
Saitoh et al, “LAT Is Essential for FcεRl-Medicated Mast Cell Activation”, Immunity, vol. 12, No. 5, May 2000, pp. 525-535.

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