Mutated form of the .beta.-amyloid precursor protein gene

Details Mutated form of the .beta.-amyloid precursor protein gene Mutated form of the .beta.-amyloid precursor protein gene

1993-10-08

1996-06-11

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, C07H 2102, C07H 2104

Patent

active

055257143

ABSTRACT:
The invention relates to a polypeptide containing a sequence of contiguous amino acids of the polypeptide sequence coded by exon 17 of the cDNA of the APP 770 gene, with said sequence of contiguous amino acids being such that:
it has from 5 to the total number of amino acids coded by said exon 17,
and it contains the amino acid corresponding to codon 692 in the cDNA of the APP 770 gene and which is alanine substituted for glycine. (no figure).

REFERENCES:
Chemical Abstracts, vol. 117, No. 17, Columbus, Ohio, US; abstract No. 168786w, Murrell, Jill; Farlow, Martin; Ghetti, Bernardino; Benson, Merrill D. "A Mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease".
Science, vol. 248, No. 4959, 1990, Lancaster, PA US, pp. 1124-1126, E. Levy et al, "Mutation of the Alzheimer's Disease . . . ".
Gene, vol. 87, No. 2, Mar. 1990, Amsterdam, NL, pp. 257-263, Shun-Ichi Yoshikai et al, "Genomic Organization . . . ".
Biochemical and Biophysical Research Communications, vol. 178, No. 3, 1991, Duluth Minnesota US, pp. 1141-1146, Katsuji Yoshioka et al, "The 717 Val . . . ".
Hendriks et al Nature genetics 1: 218-221 (1992).
Sommer et al Nucleic Acid Res (1989) 17: 6749.
Lewis Science 237: 1570 (1987).
Webster's Dictionary, II, 1984 p. 589.
Kamino et al, Am J. Hum. Genet. (1992) 51: 998-1014.

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