Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Reexamination Certificate
2008-07-22
2008-07-22
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
C435S069100, C435S193000, C435S320100, C435S252300, C435S325000, C536S023200
Reexamination Certificate
active
07402412
ABSTRACT:
A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in efficiently producing the (2R, 4R)-monatin in an amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:2.
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Kashiwagi Tatsuki
Sugiyama Masakazu
Suzuki Ei-ichiro
Watanabe Kunihiko
Ajinomoto Co. Inc.
Meah Md. Younus
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Prouty Rebecca E.
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