Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2000-09-22
2008-12-23
Fetterolf, Brandon J (Department: 1642)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07468352
ABSTRACT:
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site.
REFERENCES:
patent: 5519120 (1996-05-01), Dano et al.
patent: 5677274 (1997-10-01), Leppla et al.
patent: 5817771 (1998-10-01), Bayley et al.
Klimpel et al. (PNAS 1992; 89: 10277-10281).
Coombs et al. (J. Biol. Chem. 1998; 273: 4323-4328).
Liaw, L and Crawford, H.C., “Functions of the extracellular matrix and matrix degrading proteases during tumor progression” Braz. J. of Med. and Biol. Res. (1999) 32:805-812.
Mazar, A.P. and Jones, T.R., Abstract, XP-002131000, #146 “High-affinity, small cyclic peptide urokinase plasminogen activator receptor (uPAR)-targeting ligands localize reporter and therapeutic conjugates to the surfaces of tumor cells and stimulated endothelial cells,” Angst. Phar., 1999.
Birkedal-Hansen Henning
Bugge Thomas
Leppla Stephen H.
Liu Shi-Hui
Netzel-Arnett Sarah
Fetterolf Brandon J
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
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