Mutated alpha virus

Details Mutated alpha virus Mutated alpha virus

1994-03-21

1996-07-02

Mosher, Mary E.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435236, 4353201, 4352402, 4352523, 4352542, 4242181, 935 65, C12N 704, C12N 700, C12N 1540, A61K 3912

Patent

active

055321542

ABSTRACT:
The present invention provides a composition of matter, comprising a non-infectious, mutated virus suitable for use in preparing a vaccine. A plasmid adapted for expression in a recombinant cell comprising DNA encoding non-infectious mutated virus protein and regulatory elements necessary for expression of said DNA in the cell. Also provided are methods of inhibiting the spread of infection of a virus comprising the step of contacting said virus with a compound that inhibits thiol-reductase/protein disulfide isomerase activity in said virus.

REFERENCES:
Murphy, B. R. et al. 1985. In Virology, ed. B. N. Fields et al, Raven Press, N.Y., pp. 349-370.
Rice, C. M. et al. 1987, J. Virol. vol. 61, pp. 3809-3819.
Ivanova, L. et al. 1993. J. Virol. vol. 67, pp. 2546-2551.
Anthony, R. P. et al. 1992. Virology vol. 190 pp. 330-336.
De, B. K. et al. 1988, Vaccine vol. 6, pp. 257-261.
Tidke, R. et al. 1987, Vaccine vol. 5 pp. 229-233.
Ryser, H. J. P. et al. 1994, Proc. Natl. Acad. Sci. USA vol. 91 pp. 4559-4563.
Omar, A. et al. 1989. Virology vol. 168 pp. 177-179.
Abell, B. A., et al. 1993, J. Virol. vol. 67 pp. 5496-5501.
Kajigaya, S. et al. 1989, Proc. Natl. Acad. Sci. USA vol. 86 pp. 7601-7605.

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