Mutated adenovirus E1A gene for E1A promoter stimulation

Details Mutated adenovirus E1A gene for E1A promoter stimulation Mutated adenovirus E1A gene for E1A promoter stimulation

1988-01-04

1990-04-24

Teskin, Robin L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4351723, 435235, 435320, 435 691, 935 32, 935 27, 935 34, 935 36, 935 57, C12N 1500, C12P 2100, C07H 1512

Patent

active

049202111

ABSTRACT:
A functional mutated E1A gene of human adenovirus subgroup B:1 is provided which has a modified autorepression functional domain that is effective to express E1A products that stimulate without net repression of promoters controlling an E1A mutated gene.

REFERENCES:
patent: 4755630 (1988-10-01), Tibbetts et al.
Hearing, P., et al. (1985), Mol. Cell. Biol., 5:3214-3221.
Kosturko, L. D., et al. (1982), J. Virol., 43:1132-1137.
Larsen, et al., (1986), Virology 155:148-159.
Tibbetts, et al. (1986), J. Virol., 57:1055-1064.
Weeks, et al. (1983), Mol. Cell. Biol., 3:1222-1234.
Larsen, et al. (1987), Proc. Natl. Acad. Sci. U.S.A., 84:8185-8189.

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