Mutants of the RB and P53 genes

Details Mutants of the RB and P53 genes Mutants of the RB and P53 genes

1994-12-23

1999-10-19

Kemmerer, Elizabeth

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 4353201, C12N 1511, C12N 1563

Patent

active

059691204

ABSTRACT:
The present invention provides mutants of the Rb and p53 genes and methods utilizing these mutants therapeutically. Along with mutated Rb genes and p53 genes, the present invention provides plasmids containing a mutated Rb gene or a p53 gene. In addition, the present invention provides cells transfected with the plasmids of the present invention. Moreover, the present invention provides for methods of treating a variety of pathophysiological cell proliferative diseases.

REFERENCES:
Schulz et al., Principles of Protein Structure, Springer-Verlag, New York, pp. 14-16, 1979.
Lewin, Genes II, John Wiley and Sons, New York, p. 96, 1985.
Kern et al. 1991. Oncogene 6:131-6.
Bowie et al. 1990. Science 247:1306-10.
Friedmann. 1992. Cancer 70:1810-7.
Jain. 1994. Sci. Amer. 271(1):58-65.
Gutierrez et al. 1992. The Lancet 339:715-721.
Curti. 1993. Crit. Rev. Oncology/Hematology 14:29-39.

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