Mutants of the P4 protein of nontypable Haemophilus...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C536S023100, C536S023700, C536S024100, C435S320100, C435S071100, C435S243000, C435S252300

Reexamination Certificate

active

07666626

ABSTRACT:
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typableH. influenzae(NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.

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