Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-22
2005-03-22
Graser, Jennifer E. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C536S024100
Reexamination Certificate
active
06870042
ABSTRACT:
This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
REFERENCES:
patent: 5298396 (1994-03-01), Kotzin et al.
patent: 5336598 (1994-08-01), Kotzin et al.
patent: WOA85 00832 (1985-02-01), None
patent: WO 9314634 (1993-08-01), None
Acharya, K. et al., “Structural Basis of Superantigen Action Inferred from Crystal Structure of Toxic-Shock Syndrome Toxin-1”, Nature 367:94-97 (1994).
Aiyar, A. et al., “Modification of the Megaprimer Method of PCR Mutagenesis: Improved Amplification of the Final Product”, BioTechniques vol. 14, No. 3 (1993) pp. 366-369.
Altschyl, S. et al., “Optimal Sequence Alignment Using Affine Gap Costs”, Bulletin of Math. Biol. 48:603-616 (1986).
Anthony-Cahil, S. et al., “Site-specific mutagenesis with unnatural amino acids”, Trends in Biochem. Sci. 14:400-403 (1989).
Barsumian et al., “Nonspecific and Specific Immunological Mitogenicity by Group A Streptococcal Pyrogenic Exotoxins”, Infection and Immunity 22:681-688 (1978).
Belani, K. et al., Association of exotoxin-producing Group A streptococci and severe disease in children, Pediatr. Infect. Dis. J. 10:351-354 (1991).
Betley et al., “Staphylcoccal Enterotoxins, Toxic Shock Syndrome Toxin and Streptococcal Pyrogenic Exotoxins: A Comparative Study of their Molecuar Biology”, Chem. Immun. 55:1-35 (1992).
Birkhaug et al., “Studies in Scarlet Fever II: Studies on the Use of Convalescent Scarlet Fever Serum in Dochez Scarletino Antistreptococcie serum for the treatment of scarlet fever”, Bull. John Hopkins Hosp. 36:134-171 (1925).
Black, C.M. et al., “Detection of Streptococcal Pyrogenic Exotoxin Genes by a Nested Polymerase Chain Reaction”,Molecular and Cellular Probes, vol. 7, pp. 255-259 (1993).
Bohach et al., “Staphylcoccal and Streptococcal Pyrogenic Toxins Involved in Toxic Shock Syndrome and Related Illnesses”, Crit. Rev. Microbiol. 17:251-272 (1989).
Bowie, J. et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”, Science 247:1306-1310 (Mar. 16, 1990).
Braunstein, N. et al., “Sequences in Both Class II Major Histocompatibility Complex a and β Chains Contribute to the Binding of the Superantigen Toxic Shock Syndrome Toxin 1”, J. Exper. Med. 175:1301-1305 (Apr. 1, 1992).
Dohlsten et al., “Superantigen Induced Cytokines Supress Growth of Human Colon Carcinoma Cells”, Int. J. Cancer 54:482-488 (1993).
Fast, D. et al., “Toxic Shock Syndrome-Associated Staphylcoccal and Streptococcal Pyrogenic Toxins are Potent Inducers of Tumor Necrosis Factor Production”, Infection and Immunity 57:291-295 (Jan. 1989).
Goshorn, S. et al., “Cloning and characterization of the gene, speC, for pyrogenic exotoxin type C from Streptococcus pyogenes”, Mol. Gen. Genet. 212:66-70 (1988).
Goshorn, S. et al., “Nucelotide Sequence of Streptococcal Pyrogenic Exotoxin Type C”, Infection and Immunity 56:2518-2520 (1988).
Griggs, N. et al., “Mapping of Multiple Binding Domains of the Superantigen Staphylococcal Enterotoxin A for HLA”, J. Immunology 148:2516-2521 (Apr. 15, 1992).
Hartwig, U. et al., “Mutations affecting MHC class II binding of the superantigen streptococcal erythrogenic toxin A.” International Immunology 5(8):869-875.
Hattori, M. et al., “Structure of the rat α2—macroglobulin-coding gene”, Gene 77:333-340 (1989).
Hauser, A. et al., “Molecular Analysis of Pyrogenic Exotoxins from Streptococcus pyogenes Isolates Associated with Toxic Shock-Like Syndrome”, J. Clin. Microbiol. 29:1562-1567 (Aug. 1991).
Hedlund et al., “Superantigen-Based Tumor Therapy in Vivo Activation of Cytotoxic T Cells”, Cancer Immun. Immunother. 36:89-93 (1993).
Hsiao, Ku-chuan et al., “A Fast and simple procedure for sequencing double stranded DNA with Seqenase”, Nucleic Acids Research 19:2787 (1991).
Ihle et al., “Antibody Targeted Super Antigens Induce Lysis of Major Histocompatibility Complex Class II Negative T Cell Leukemia Lines”, Cancer Res. 55:623-628 (1995).
Iwasaki et al., “Cloning, Characterization and Overexpression of Streptococcus Pyogenes Gene Encoding a New Type of Mitogenic Factor”, FEBS Lett. 331:187-192 (1993).
Jardetzky, T. et al., “Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen”, Nature 368:711-718 (Apr. 21, 1994).
Jett et al., “Identification of Staphylcoccal Enerotoxin B Sequences Important for Induction of Lymphocyte Proliferation Using Synthetic Peptide Fragments of the Toxin”, Infection and Immunity 62:3408-3415 (1994).
Johnson, L. et al., “Group A streptococcal phage T12 carries the structural gene for pyrogenic exotoxin type A”, Mol. Gen. Genet. 194:52-56 (1994).
Kappler, J. et al., “Mutations Defining Functional Regions of the Superantigen Staphylcoccal Enterotoxin B.”, J. Exp. Med. 175:387-396 (Feb. 1992).
Lee, P. et al., “Effects of Staphylococcal Toxic Shock Syndrome Toxin I on Aortic Endothelial Cells”, J. Infect. Dis. 164:711-9 (1991).
Lee, P. et al., “Fluid Replacement Protection of Rabbits Challenged Subcutanteously with Toxic Shock Syndrome Toxins”, Infection and Immunity 59(3):879-884 (Mar. 1991).
Marrack, P. et al., “The Staphylcoccal Enterotoxins and Their Relatives”, Science 248:705-711 (May 1990).
Martin, D., et al., Molecular Epidemiology of Group A Streptococcus M Type 1 Infections, J. Infect. Dis. 167:1112-7 (1993).
Mollick, J. et al., “Localization of a Site on Bacterial Superantigens That Determines T Cell Receptor β Chain Specificity”, J. Exp. Med. 177:283-293 (Feb. 1993).
Mollick, J. et al., “Novel Superantigen Isolated from Pathogenic Strains of Streptococcus pyogenes with Aminoterminal Homology to Staphylcoccal Enterotoxins B and C”, J. Clin. Invest. 92:710-719 (Aug. 1993).
Murray, D. et al., “Immunobiologic and Biochemical Properties of Mutants of Toxic Shock Syndrome Toxin-1”, J. Immunol (US) (1994) 152(1):87-95.
Musser et al., “Streptococcus Pyogenes Causing Toxic Shock-like Syndrome and Other Invasive Diseases: Colonal Diversity and Pyrogenic Exotoxin Expression”, Proc. Nat'l. Acad Sci. (USA) 88:2668-2672 (1991).
Musser, J. et al., “Infect Immun”, Mar. 1995, 63(3) P994-1003.
Nelson, K. et al., “Characterization and Clonal Distribution of Four Alleles of the speA Gene Encoding pyrogenic Exotoxin A (Scarlet Fever Toxin) inStreptococcus pyogenes”, . Exp. Med., 174:1271-1274 (Nov. 1991).
Norrby-Teglund, A. et al., “Relation between Low Capacity of Human Sera to Inhibit Streptococcal Mitogens and Serious Manifestation of Disease”, J. Infect. Dis. 170:585-91 (1994).
Perrin, S. et al., “Site-specific mutagenesis using asymmetric polymerase chain reaction and a single mutant primer”, Nucleic Acids Research 18:7433-7438 (1990).
Prasad, G. et al., “Structure of Toxic Shock Syndrome Toxine 1”, Biochemistry vol. 32, No. 50 (Dec. 21, 1993) 50:13761-13766.
Rennell, D. et al., “Systematic Mutation of Bacteriophage T4 Lysozyme”, J. Mol. Biol. 222:67-87 (1991).
Revie, D., et al., “Kinetic analysis for optimization of DNA ligation reactions”, Nucleic Acids Research 16:10301-10321 (1988).
Roggiani, A. et al., “Localization of biological activities of Streptococcal Pyrogenic Exotoxin”, poster presentation at the ASM 94thGeneral Mee
Ohlendorf Douglas
Roggiani Manuela
Schlievert Patrick M.
Stoehr Jennifer
Graser Jennifer E.
Merchant & Gould P.C.
Regents of the University of Minnesota
LandOfFree
Mutants of streptococcal toxin A and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutants of streptococcal toxin A and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutants of streptococcal toxin A and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3385398