Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2008-05-22
2010-02-09
Saoud, Christine J (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C536S023510
Reexamination Certificate
active
07659379
ABSTRACT:
Mutants of human FGF-1 are disclosed having increased stability and mitogenic potency. In the FGF-1 polypeptide, primarily residues 12 and 134 are substituted with cysteine, valine or threonine to render the polypeptide more stable and/or to increase its mitogenicity.
REFERENCES:
Brych et al. Protein Science, 12: 2704-2718, 2003.
Brych et al. Journal of Molecular Biology, 344: 769-780, 2004.
Blaber Michael
Dubey Vikash Kumar
Allen Dyer Doppelt Milbrath & Gilchrist, P.A.
Florida State University Research Foundation, Inc.
Saoud Christine J
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