Mutant uricase, a mutant uricase gene, a novel recombinant DNA,

Details Mutant uricase, a mutant uricase gene, a novel recombinant DNA, Mutant uricase, a mutant uricase gene, a novel recombinant DNA,

1996-08-23

1997-12-23

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435 691, 43525233, 4353201, 536 232, C12N 906, C12N 120, C12P 2106, C07H 2104

Patent

active

057006741

ABSTRACT:
The present invention relates to mutant uricase containing the amino acid sequence of wild-type uricase shown in SEQ ID NO: 1 wherein the 165-170th amino acids contain a mutated amino acid sequence, a mutant uricase gene coding for said uricase, a recombinant DNA having said mutant uricase gene integrated into a vector DNA, and a process for producing mutant uricase by culturing a microorganism carrying said recombinant DNA and having the ability to produce mutant uricase in a medium, and then recovering mutant uricase from the culture. The present invention provides stable mutant uricase and the gene coding for said mutant uricase, and further the process of the present invention enables efficient production of stable uricase.

REFERENCES:
patent: 5376545 (1994-12-01), Yagasaki et al.

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