Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8

Details Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8 Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8

1991-06-04

1993-10-05

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

435125, 435146, 435913, 549214, 549292, 514460, C12P 742, C12P 1706, C12N 114, C07D30500

Patent

active

052504352

ABSTRACT:
Novel strains of Aspergillus terreus have been discovered which provide fermentation production of at least 5.2 g/L of 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl ]-3(R),5(R)-dihydroxyheptanoic acid (triol acid, I), but with production of not more than 0.85 g/L of (triol acid)-related side products and specifically less than 0.10 mg/liter of lovastatin. The predominant fermentation product triol acid, may be converted in a straightforward manner to its lactone form, in which it is an inhibitor of HMG-CoA reductase and thus useful as an antihypercholesterolemic agent, and in which it may also serve as an intermediate for preparation of other HMG-CoA reductase inhibitors.

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Nakamura et al. Isolation & Biosynthesis of 3.alpha.hydroxy-3,5-hihydromonacolin L, The Journal of Antibiotics 43(12) 1990 pp. 1597-1600.
M-S Shiao et al., Proc. Nat'l Sci. Counc. B. Roc, 11:223-231 (1987).
Endo et al., J. Antibiotics, 39 1670 (1989).

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