Mutant strain of Listeria monocytogenes and its use in productio

Details Mutant strain of Listeria monocytogenes and its use in productio Mutant strain of Listeria monocytogenes and its use in productio

1983-08-02

1986-01-28

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 85, 260112R, 260112B, A61K 3940, A61K 39395, C07G 700

Patent

active

045670412

ABSTRACT:
A novel mutant strain of Listeria monocytogenes has been discovered which functions as a killed strain not only as an antigen resulting in the production of relatively large titers of IgM antibodies in host animals but also as an immunopotentiating agent when conjugated to a sensitising antigen, for example, living tumor cells and herpes simplex virus. The high molecular weight IgM antibodies are readily separated from serum and recovered without loss of appreciable activity. The IgM antibodies can be divided into five subunits of IgG antibodies, of lesser molecular weight, having the same specificity as the IgM immunoglobulins. When the sensitizing antigens conjugated with the Listeria monocytogenes strain of this invention are tumor cells, the conjugate acts as an immunotherapeutic agent effective in cancer immunotherapy.

REFERENCES:
patent: 3766162 (1973-10-01), Spector et al.
patent: 3809782 (1974-05-01), Spector

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