Mutant S182 genes

Details Mutant S182 genes Mutant S182 genes

1996-06-26

1999-10-26

Stanton, Brian R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 530350, 514 2, 514 44, 800 12, 435 4, 435 6, C07H 2104

Patent

active

059731338

ABSTRACT:
The invention provides novel mutant S182 sequences, methods of diagnosing Alzheimer's disease using these novel mutant S182 genes, a model system for Alzheimer's disease comprising a mutant S182 gene, and methods of identifying mutations in genes homologous to the S182 gene.

REFERENCES:
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patent: 5545808 (1996-08-01), Hew et al.
Pursel et al. Genetic Engineering of Livestock. Science, vol. 244, pp. 1281-1288, Jun. 16, 1989.
Houdebine, L. M. Production of pharmaceutical proteins from transgenic animals. J. of Biotech., vol. 34, pp. 269-287, 1994.
Salter, et al. Transgenic chickens: insertion of retroviral genes into the chicken germ line. Virology, vol. 157, pp. 236-240, 1987.
Sherrington et al. Cloning of gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature, vol. 375, pp. 754-760, Jun. 29, 1995.
Wragg et al. Animal models of Alzheimer's disease. Adaptations in Aging, Academic Press, pp. 157-172, 1995.
Price et al. Biology of Alzheimer's disease and animal models. The American Psychiatric Press textbook of Psychopharmacology, American Psychiatric Press, Inc, pp. 523-535, 1995.

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