Mutant respiratory syncytial virus (RSV), vaccines containing sa

Details Mutant respiratory syncytial virus (RSV), vaccines containing sa Mutant respiratory syncytial virus (RSV), vaccines containing sa

1993-05-07

1999-08-03

Scheiner, Laurie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241841, 4242781, 435237, A61K 39155, C12N 708

Patent

active

059322225

ABSTRACT:
This invention provides cold adapted mutant RSV, specifically, mutant RSV of subgroup A and B. Nucleic acid molecules encoding the mutant RSV of this invention, and immunogenic polypeptides of these mutant RSV also are provided by this invention. Pharmaceutical compositions containing any of the above compositions are provided herein. These are especially useful as vaccines. Further provided by this invention are methods of vaccinating a subject against RSV infection using the pharmaceutical compositions described herein.

REFERENCES:
Maassab, et al., "Development and characterization of cold-adapted viruses for use as live virus vaccines", Vaccine, vol. 3:355-369 (1985).
Belshe, et al., "Cold Adaptation of Parainfluenza Virus Type 3: Induction of Three Phenotypic Markers", Journal of Medical Virology 10:235-242 (1982).
Murphy, et al., "A Cold-adapted Mutant of Human Parainfluenza Virus Type 3 Is attenuated and Protective in CHimpanzees", Vaccines 90:91-95 (1990).
Friedewald, W. T. et al., "Low-Temperature-Grown RS Virus in Adult Volunteers," The J. of the American Medical Association 204(8) :690-694 (1968).
Wright et al., Infection and Immunity, vol. 37, No. 1, Jul. 1982 pp. 397-400.
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McIntosh et al Virology 2.sup.nd Ed, Edited by B.N.
Fields et al, Raven Press, N.Y. pp. 1045-1072, 1990.
Hall, C. B. Science 265:1393-1394, 1994.
Mufson et al J. Clinical Microbiology 25(8): 1535-1539 1987.
McKay et al J. Med. Virology 25:411-421, 1988.
Kim et al, "Clinical and Immunological Response of Infants and Children to Administration of Low-Temperature Adapted Respiratory Syncytial Virus," Pediatrics 48(5): 745-755, 1971.
Freymuth et al, "Prevalence of Respiratory Syncytial Virus Subgroups A and B in France from 1982 to 1990" J. of Clinical Microbiology 39(3) :653-655, 1991.

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