Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2002-10-28
2009-02-10
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S194000, C435S252300, C435S320100, C536S023200, C514S04400A
Reexamination Certificate
active
07488598
ABSTRACT:
A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. A nucleotide sequence encoding mutantE. coliderived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth is also provided. A method is detailed for the delivery of toxin by generation within target cells or by administration and delivery to the cells from without. Novel purine nucleosides are detailed that yield a cytotoxic purine upon enzymatic cleavage. A synthetic process for nucleosides is also detailed.
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Ealick Steven E.
Parker William B.
Secrist, III John A.
Sorscher Eric J.
Cornell Center for Technology Enterprise and Commercialization
Gifford Krass Sprinkle Anderson & Citkowski P.C.
Saidha Tekchand
Southern Research Institute
The UAB Research Foundation
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