Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1995-01-25
1997-12-09
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4352351, 4351723, 435236, 4242051, 4242291, A61K 39245, A61K 39295, C12N 701, C12N 704
Patent
active
056957653
ABSTRACT:
The invention relates to a pseudorabies virus (PRV) not found in nature and having a genome containing a mutation in the protein kinase gene region and/or in the 28K gene region. The mutation is e.g. a nucleic acid substitution, deletion, insertion or inversion, or a combination thereof. The mutations are introduced, by genetic engineering techniques, into the genome of a naturally occuring PRV, preferably NIA-3. Insertions may be nucleic acid sequences encoding antigenic polypeptides characteristic of a pathogen found in pigs. The invention also relates to vaccines containing a pseudorabies virus according to the invention, and to a process for preparing such vaccines.
REFERENCES:
Van Zijl et al. J. Virol. 62(6):2191-95 1988.
Thomsen, D.R. et al. Gene, vol. 57, pp. 261-265, 1987.
"Deletions in the Genomes of Pseudorabies Virus Vaccine Strains and Existence of Four Isomers of the Genomes", Journal of Virology, vol. 49, No. 3, Mar. 1984, pp. 970-979, copyright 1984, by American Society for Microbiology.
"Pseudorabies Virus Avirulent Strains Fail to Express a Major Glycoprotein", Journal of Virology, vol. 56, No. 1, Oct. 1985, pp. 307-311, copyright 1985 by American Society for Microbiology.
"Herpes Simplex Virus 1 Protein Kinase Is Encoded by Open Reading Frame US3 Which Is Not Essential for Virus Growth in Cell Culture" Journal of Virology, vol. 61, No. 5, Sep. 1987, pp. 2896-2901, copyright 1987 by American Society for Microbiology.
"Construction and Characterization of Deletion Mutants of Pseudorabies Virus: a New Generation of Live Vaccines", J. gen. Virol, vol. 68, 1987, pp. 523-534, by W. Quint et al.
"Deletions in Vaccine Strains of Pseudorabies Virus and Their Effect on Synthesis of Glycoprotein gp63", Journal of Virology, vol. 60, No. 3, Dec. 1986, pp. 1166-1169, copyright 1986, by American Society for Microbiology.
Berns Antonius Jozef Maria
De Wind Niels
Gielkens Arnold Leonard Jozef
Van Zijl Maria Madalene
Mosher Mary E.
Stichting Voor De Technische Wetenschappen
LandOfFree
Mutant pseudorabies virus, and vaccines containing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutant pseudorabies virus, and vaccines containing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant pseudorabies virus, and vaccines containing the same will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1605593