Mutant proline-and-arginine rich peptides and methods for...

Details Mutant proline-and-arginine rich peptides and methods for... Mutant proline-and-arginine rich peptides and methods for...

2007-02-12

2011-10-04

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C514S021500, C514S021600

Reexamination Certificate

active

08030446

ABSTRACT:
The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating expression of genes regulating the NF-κB pathway. Mutant PR peptides of the present invention differ from wild-type PR peptides by having at least one to three amino acid substitutions, wherein at least one of the amino acid residues at position one, two or three of the mutant PR peptide is positively charged.

REFERENCES:
patent: 4504469 (1985-03-01), Melin et al.
patent: 4704692 (1987-11-01), Ladner
patent: 5013657 (1991-05-01), Bryan et al.
patent: 5241470 (1993-08-01), Lee et al.
patent: 6133233 (2000-10-01), Ross et al.
patent: 7345021 (2008-03-01), Simons et al.
patent: 2006/0205645 (2006-09-01), Compernolle et al.
Anbanandam, Asokan (Journal of Molecular Biology 384(1), 219-227, 2008).
Bao et al., “PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated IkaapaBetaAlpha degradation”, Am J Physiol Heart Circ Physiol 2001 281:H2612-H2618.
Gaczynska et al., “Proline-and Arginine-Rich Peptides Constitute a Novel Class of Allosteric Inhibitors of Proteasome Activity”, Biochemistry 2003 42:8663-8670.
Gao et al., “Inhibition of ubiquitin-proteasome pathway-mediated IkappaBetaAlpha degradation by a naturally occurring antibacterial peptide”, J. Clin. Invest. 2000 106:439-448.

Affiliated with

Also associated with

Rating

Mutant proline-and-arginine rich peptides and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mutant proline-and-arginine rich peptides and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant proline-and-arginine rich peptides and methods for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4280740