Mutant prenyl diphosphate synthase

Details Mutant prenyl diphosphate synthase Mutant prenyl diphosphate synthase

1997-07-01

2000-03-21

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4352523, 4353201, 435440, 435832, 536 232, C12N 910, C12N 120, C12N 100, C07H 2104

Patent

active

060401656

ABSTRACT:
Manufacture or use of a mutant prenyl diphosphate synthase in which the amino acid residue located at the fifth position in the N-terminal direction from D of the N-terminal of the aspartic acid-rich domain DDXX(XX)D (the two X's in the parentheses may not be present) present in the second region among the conserved regions of the prenyl diphosphate synthase has been substituted by another amino acid.

REFERENCES:
Ohnuma et al. (Aug. 2, 1996) vol. 271, pp. 18831-18837.
Math, et al., Proc. Natl. Acad. Sci. USA, vol. 89, Aug. 1992, pp. 6761-6764.
Ohnuma, et al., J. Biol. Chem., 269:20, May 20, 1994, pp. 14792-14797.
Marrero et al., J. Biol. Chem., 267:30, pp. 21873-21878, Oct. 25, 1992.
Koyama et al., J. Biochem, 113:3, pp. 355-363, 1993.
Koike-Takeshita et al., J. Biol. Chem., 270:31, pp. 18396-18400, 1995.
Koyama et al., Biochem., 33:42, pp. 12644-12648, 1994.
Koyama et al., Biochem., 35:29, pp. 9533-9538, 1996.
Ohnuma et al., J. Biol. Chem., 271:17, pp. 10087-10095, 1996.
Tarshis et al., Biochem., 33:36, pp. 10871-10877, 1994.
Koyama et al., Can. J. Chem., 72:75-79, 1994.

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