Mutant possessing uracil phosphoribosyl transferase activity

Details Mutant possessing uracil phosphoribosyl transferase activity Mutant possessing uracil phosphoribosyl transferase activity

2006-05-23

2006-05-23

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S227000, C435S325000, C435S455000, C435S456000, C435S471000, C435S093000, C435S252300, C424S094500, C514S04400A, C536S023100, C536S023200, C536S023400, C536S023740

Reexamination Certificate

active

07049117

ABSTRACT:
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.

REFERENCES:
patent: 5856153 (1999-01-01), Tiraby et al.
patent: 6066624 (2000-05-01), Woo et al.
patent: 96/16183 (1996-05-01), None
patent: WO 96/16183 (1996-05-01), None
Kern, L. et al, “The FUR1 Gene ofSaccharomyces Cerevisiae: Cloning, Structure and Expression of Wild-Type and Mutant Alleles”, Gene Apr. 16, 1990, 88(2), 149-57, Elsevier Science Publishers B.V. (Biomedical Division).
Martinussen et al., “Two Genes Encoding Uracil-Phosphoribosyltransferase are Present inBacillus Subtilis,” J. Bacteriol. 177 (1):271-274, Jan. 1995, Am. Soc. of Microbiology, Wash., D.C.
GenBank Acc. No. CAB11230, “Uracil Phosphoribosyltransferase (Schizosaccharomyces Pombe),” US Natl. Library of Medicine, Bethesda, MD, Apr. 04, 2000, accessed by PTO on Nov. 04, 2002.
Ngo et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox”, in The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 and 492-495, 1994.

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