Mutant pneumolysin proteins

Details Mutant pneumolysin proteins Mutant pneumolysin proteins

2005-05-09

2010-10-26

Robinson, Hope A (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C435S007100, C435S325000

Reexamination Certificate

active

07820789

ABSTRACT:
The invention relates to immunogenic compositions comprising mutantStreptococcus pneumoniaepneumolysin proteins. The invention further relates to such proteins and nucleic acids encoding these proteins. In particular embodiments, the invention is directed to an isolated mutant pneumolysin (PLY) protein, wherein the mutant PLY protein differs from the wild-type PLY protein of SEQ ID NO:1 presence of a mutation within the region of amino acids 144 to 161 of the wild type such that the toxicity of the mutant is reduced relative to that of the wild-type protein. In particular embodiments, the mutant PLY protein differs from the wild-type protein by the substitution or deletion of amino acids including the deletion of two adjacent amino acids within the region of amino acids 144 to 151 of the wild-type sequence.

REFERENCES:
patent: 5565204 (1996-10-01), Kuo et al.
Wells, Biochemistry, vol. 29, pp. 8509-8517, 1990.
Seffernick et al. (J. Bacteriology, vol. 183, pp. 2405-2410, 2001.

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