Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-07-28
1996-06-25
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 4351723, 4352402, 4353201, 935111, C12N 500, C12N 1500
Patent
active
055301789
ABSTRACT:
A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mammals, for example, mice, CD8.sup.+ T lymphocytes are not present in peripherial lymphoid organs, but the CD4.sup.+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not effected. These mice should be useful for drug development and for studies of diseases of the immune system such as, autoimmunity, immunodeficiency, transplant rejection and tumor rejection.
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Chambers Jasemine C.
The Ontario Cancer Institute
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