Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1995-06-07
1997-07-22
Campbell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 4351723, 435354, 935 10, 935 70, C12N 500, C12N 1500
Patent
active
056505507
ABSTRACT:
The present invention provides a mutant non-human vertebrate, in which all or some of the germ and somatic cells contain a mutation in at least one steroid hormone receptor allele, which mutation is introduced into the vertebrate, or an ancestor of the vertebrate, at an embryonic stage, and which mutation produces a phenotype in the vertebrate characterized by a deficit of functional steroid hormone receptors encoded by the allele. Also disclosed are related methods and constructs.
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Korach Kenneth S.
Lubahn Dennis B.
Smithies Oliver
Campbell Bruce R.
The United States of America as represented by the Department of
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