Mutant luciferase of a firefly, mutant luciferase genes, recombi

Details Mutant luciferase of a firefly, mutant luciferase genes, recombi Mutant luciferase of a firefly, mutant luciferase genes, recombi

1991-03-26

1993-06-15

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 711, 435 712, 4351721, 4351723, 435189, 4352523, 43525233, 4353201, 536 232, 935 10, 935 14, 935 27, 935 56, C12N 902, C12N 1553

Patent

active

052197379

ABSTRACT:
The present invention provides industrially useful luciferase. Mutant luciferase of the invention is produced by culturing a microorganism belonging to the genus Escherichia which harbors a recombinant DNA containing the mutant luciferase gene of a firefly. Mutant luciferase can produce red, orange or green color of light which can not be produced by wild type luciferase. Mutant luciferase can be used to measure ATP accurately in a colored solution such as red (e.g., blood), orange, or green in which wild-type luciferase has not provided reliable results.

REFERENCES:
patent: 4320195 (1982-03-01), Hill et al.
patent: 4743561 (1988-05-01), Shaffer
Masuda et al. "Cloning and Sequence Analysis of CDNA . . . " Gene 77: 265-270 (1989).
Chu et al. "Hydroxylamine Mutagenesis of HSV DNA . . . " Virology 98: 161-181 (1979).
de Wet et al. "Firefly Luciferase Gene: Structure and . . . " Mol. and Cell. Biol. 7: 725-737 (Feb. 1987).
Wood et al., 1989, J. Bioluminescence and Chemiluminescence 4:289-301.
Wood et al., 1989, J. Bioluminescence and Chemiluminescence 4:31-39.
Wood, J. Bioluminescence and Chemiluminescence 5:107-114 (Paper associated with talk presented at: Symposium on Lux Genes: Basics, Applications and Commercial Prospects, Cambridge, U.K., Dec. 1989).
DeWet et al., 1985, Proc. Natl. Acad. Sci., USA, 82:7870-7873.
Wood et al., 1989, Science, 244:700-702.

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