Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Reexamination Certificate
2003-03-19
2008-11-04
Bragdon, Kathleen Kerr (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
C435S107000, C435S108000, C435S110000, C435S114000, C435S115000, C435S183000, C435S233000, C435S252300, C435S252320, C435S253100, C536S023200
Reexamination Certificate
active
07445915
ABSTRACT:
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform bacterium which produces the polypeptide comprising the amino acid sequence as the sole isopropylmalate isomerase exhibits a partial leucine requirement in a minimal medium; a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism transformed with the recombinant DNA, and a process for producing an L-amino acid using the microorganism.
REFERENCES:
patent: 7141663 (2006-11-01), Zelder et al.
patent: 1108790 (2001-06-01), None
patent: WO 03/040681 (2003-05-01), None
patent: WO 03/054179 (2003-07-01), None
WO200100843-A2 Pompejus et al.Corynebactriumglutamicumgenes that encode metabolic pathway proteins.
Nakayama et al. Microbial production of Essential amino acids withCorynebactrium glutamicummutants. Advances in Experimental Medicine and Biology, 1978 vol. 105:649-661.
Patek et al. Leucine synthesisi inCorynebactrium glutamicum: Enzyme activities, Structure of leuA, and effect of leuA Inactivation on Lysine Synthesis. Applied and Environmental Microbiology Jan. 1994, vol. 60, p. 133-140.
Schrumpf et al A Functional Split pathway for Lysine synthesis inCorynebactrium glutamicum. Journal of Bacteriology, Jul. 1991, vol. 173 pNo. 14, p. 4510-4516.
Hermann Sahm, et al.; “Isolation and Prominent Characteristics of an L-Lysine Hyperproducing Strain ofCorynebacterium glutamicum”; Appl., Microbiol. Biotechnol., vol. 37, 1992, pp. 566 to 571.
Hermann Sahm, et al: “Leucine Synthesis inCorynebacterium glutamicum: Enzyme Activities, Structure of Leua, and Effect of Leua Inactivation on Lysine Synthesis”; Appl. Microbiol. Biotechnol, vol. 60, No. 1, 1994, pp. 133-140.
English translation of International Preliminary Examination Report dated Dec. 9, 2004 issued in PCT/JP2003/003353.
Hayashi et al, AleuCmutation leading to increased L-lysine production andrel-independent global expression changes inCorynebacterium glutamicum, Appl Microbiol Biotechnol, 72, 783-9 (2006).
Hayashi Mikiro
Ikeda Masato
Mitsuhashi Satoshi
Mizoguchi Hiroshi
Nakagawa Satoshi
Bragdon Kathleen Kerr
Gebreyesus Kagnew H.
Kyowa Hakko Kogyo Co. Ltd.
Nixon & Vanderhye P.C.
LandOfFree
Mutant isopropylmalate isomerase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutant isopropylmalate isomerase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant isopropylmalate isomerase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4026672