Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-05-05
1997-10-28
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 695, 435 6951, 435243, 4352523, 4353201, 530351, 930141, 930142, 930140, 536 235, 536 2352, 424 852, 424 856, C12P 2102, C07H 2104, C07K 1452, A61K 3820
Patent
active
056817231
ABSTRACT:
The present invention is drawn to mutant interleukin 6, which has the amino acid arginine in position 176, replacing serine in position 176 with wild-type interleukin 6. The mutant interleukin 6 of the present invention has greater biological activity than the wild-type protein. The present invention is further drawn to methods of making mutant interleukin 6, having arginine at position 176 and methods of using the same.
REFERENCES:
patent: 5210075 (1993-05-01), Scholz et al.
de Hon et al, Cytokine 7(5) 1995, p. 398-407.
Thier et al J. Neurosci Res. 40(6) 1995, pp. 826-835.
Skelly et al J. Biotechnol 34(1) 1994, pp. 79-86.
Savino et al, PNAS 90, 1993, pp. 4067-4071.
Fontaine et al Eur. J. Biochem. 211, 1993, pp. 749-755.
Li et al, JBC 268 (32) 1993, PP. 22377-22384.
Leebeek et al JBC 267(21) 1992, pp. 14832-14838.
Brakenhoff et al JBC 269(1) 994, pp. 86-93.
"Biochem. Biophys. Res. Communications" vol. 187, No. 1, Aug. 31, 1992, pp. 8-25.
"FEBS Letters" vol. 282, No. 2, pp. 265-267.
"Gene" vol. 104, No. 2, 1991, Amsterdam, pp. 227-234.
Ciliberto Gennaro
Savino Rocco
Draper Garnette D.
Instituto di Ricerche di Biologia Molecolare P. Angelett S.P.A.
LandOfFree
Mutant interleukin 6 with improved biological activity over wild does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutant interleukin 6 with improved biological activity over wild, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant interleukin 6 with improved biological activity over wild will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1025449