Mutant interferon α protein and use thereof

Details Mutant interferon α protein and use thereof Mutant interferon α protein and use thereof

2005-11-09

2010-02-23

Saoud, Christine J (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

C435S069510, C530S351000, C530S402000, C424S085400

Reexamination Certificate

active

07666403

ABSTRACT:
The present invention has objects to provide a mutant interferon-α protein having a higher anti-viral and anti-tumor activity and to provide an agent for susceptive diseases, which contains the mutant interferon-α protein as an effective ingredient; and solves the above objects by providing a mutant protein which has an amino acid sequence of human interferon-α subtype α8 represented by any one of SEQ ID NOs:1 to 3, where the arginine residue at the 145thhas been replaced with leucine, isoleucine, or valine residue; the alanine residue at the 146thhas been replaced with asparagine or serine residue; and the methionine residue at the 149thhas been replaced with tyrosine residue; and an agent for susceptive diseases, containing the mutant protein.

REFERENCES:
Extended European Search Report mailed Sep. 10, 2008.
Kallen, K.-J. et al., “New perspectives on the design of cytokines and growth factors”, Trends in Biotechnology, Elsevier Publications, vol. 18, No. 11, pp. 455-461, Nov. 1, 2000.
L. C. Roisman et al., “Mutational Analysis of the IFNAR1 Binding Site on IFNa2 Reveals the Architecture of a Weak Ligand-Receptor Binding-Site”, Journal of Molecular Biology, vol. 353, No. 2 pp. 271-281, Oct. 21, 2005.
H. Schooltink et al., “Designing Cytokine Variants by Phage-Display”, Combinatorial Chemistry & High Throughput Screening, vol. 8, No. 2, pp. 173-179, Mar. 2005.
H. Renqui et al., “Protein Engineering of Interferon Alphas”, Methods in Molecular Medicine, vol. 116, pp. 69-80, 2005.

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